Lactoferrin With Royal Jelly
Sep 5, 2023
Children’s chewable
IMMUNE SUPPORT
Lactoferrin with Royal Jelly is prepared with goat milk and royal jelly that supplies nutrients, and growth factors for support of the immune system in children.
Lactoferrin is a peptide glycoprotein that belongs to the transferrin family and plays a role in binding and transporting iron in the body, as well as immunomodulatory and antioxidant activities, it is a natural anti-viral, anti-bacterial and anti-inflammatory that supports the immune system and gut microflora, promote healthy sleep (1-9).
Royal Jelly is a mix of yellow-white secretions produced by the worker honeybees to supply a principal food for the queen honeybee. It is rich in minerals (mainly calcium and iron), vitamins (riboflavin, niacin, thiamine and B6, vit E), carbohydrates, and proteins fatty acids, sugars, biotin, sulfur, phosphorus, proteins, and essential amino acids.
Features:
May provide a bacteriostatic effect by binding iron to itself, starving viruses and bacteria of the iron necessary for their survival.
May provide an immunomodulatory effect and enhance the body’s immune response
May support gut Health, by promoting the growth of selected probiotic strains.
May improve sleep
Lactoferrin is a protein naturally found in breast milk (cow milk and human milk), and is also found in fluids in the eye, nose, respiratory tract, intestine, and elsewhere. The antiviral properties of lactoferrin make it a great natural supplement that could also be used as an adjunct for COVID-19 and for various other Respiratory Tract Infections (RTIs) according to a team of researchers led by the University of Huddersfield (10). It was found that Lactoferrin intake may improve sleep conditions, especially morning symptoms in children above one year of age. (11-12)
Royal jelly for children is a great activator of the immune system since it helps fight infections and has revitalizing properties, increasing the body’s resistance. Compounds of Royal Jelly like jelleins, royalisin, MRJPs, royalactin, and apisimin could be classified as antimicrobial peptides, appear to be a natural alternative to conventional antibiotic (13)
Reference:
1.Oda H, Wakabayashi H, Tanaka M, Yamauchi K, Sugita C, Yoshida H, Abe F, Sonoda T, Kurokawa M. Effects of lactoferrin on infectious diseases in Japanese summer: A randomized, double-blinded, placebo-controlled trial. J Microbiol Immunol Infect. 2021 Aug;54(4):566-574.
2.Hu Y, Meng X, Zhang F, Xiang Y, Wang J. The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor. Emerg Microbes Infect. 2021 Dec;10(1):317-330
3.Wakabayashi H, Oda H, Yamauchi K, Abe F. Lactoferrin for prevention of common viral infections. J Infect Chemother. 2014 Nov;20(11):666-71.
4.Vitetta L, Coulson S, Beck SL, Gramotnev H, Du S, Lewis S. The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: a double blind randomized study. Complement Ther Med. 2013 Jun;21(3):164-71.
5.Kevin K. Darmawan, Tom C. Karagiannis, Jeff G. Hughes, Darryl M. Small, Andrew Hung. (2022) Molecular modeling of lactoferrin for food and nutraceutical applications: insights from in silico techniques. Critical Reviews in Food Science and Nutrition 0:0, pages 1-24.
6.Yamauchi K, Wakabayashi H, Hashimoto S, Teraguchi S, Hayasawa H, Tomita M. Effects of orally administered bovine lactoferrin on the immune system of healthy volunteers. Adv Exp Med Biol. 1998;443:261-5.
7.Mohamed WA, Salama RM, Schaalan MF. A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway. Biomed Pharmacother. 2019 Mar;111:714-723.
8.Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Frum T, Kadambi NS, Amin AT, O'Meara TR, Pretto CD, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Sexton JZ. Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. bioRxiv [Preprint]. 2020 Dec 7:2020.05.27.117184.
9.Wotring, Jesse W. et al.Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern Journal of Dairy Science, Volume 105, Issue 4, 2791 – 2802
10. Akbar Shoukat Ali, Syed Shahzad Hasan, Chia Siang Kow, Hamid A. Merchant, Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials, Clinical Nutrition ESPEN, Vol 45, 2021,Pp 26-32.
11.Uesaki, S. & Imanaka, Hiromichi & Suido, Hirohisa & Suwa, M. & Matsumoto, M. & Kondo, S.. (2018). Effects of lactoferrin supplementation on sleep quality, mood states, and enteric environment in poor sleepers-Randomized, placebo-controlled, double-blind study-. Japanese Pharmacology and Therapeutics. 46. 55-63
12.Miyakawa M, Kubo S, Oda H, Motoki N, Mizuki M, Tsukahara T, Tanaka M, Yamauchi K, Abe F, Nomiyama T. Effects of Lactoferrin on Sleep Conditions in Children Aged 12-32 Months: A Preliminary, Randomized, Double-Blind, Placebo-Controlled Trial. Nat Sci Sleep. 2020 Sep 29;12:671-677.
13. Collazo N, Carpena M, Nuñez-Estevez B, Otero P, Simal-Gandara J, Prieto MA. Health Promoting Properties of Bee Royal Jelly: Food of the Queens. Nutrients. 2021 Feb 7;13(2):543.
